GeneTex Histone H2A.XS139ph (phospho Ser139) antibody [EP854(2)Y]

Кроличьи моноклональные антитела ДженТекс, выборка антител по технологии RMAb.

Histones are basic nuclear proteins that are responsible for the structure of eukaryotic chromosomal fibers. H2AX is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle. Double-stranded breaks in DNA caused by replication errors, apoptosis, physiological processes and DNA damage caused by ionizing radiation, UV light or cytotoxic agents lead to phosphorylation of H2AX on serine 139. H2AX (pS139) is also referred to as H2AX (pS140) when the N-terminal methionine that is normally excised during posttranslational processing is included in amino acid sequence numbering. The phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs. The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner.

• Выборка антител, приготовленных по технологии RMAb
• Полный перечень антител GeneTex

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