GeneTex NFkB p65 (phospho Ser529) antibody [EPR2379]

Кроличьи моноклональные антитела ДженТекс, выборка антител по технологии RMAb.

Nuclear factor B (NF-B) encompasses an important family of inducible transcriptional activators that regulate a wide variety of cellular and viral genes . They play a role as transcription factors in the adaptive immune response, inflammation, and apoptosis . The p65 subunit, similar to two others in the B family, RelB and c-Rel, contains two transactivation domains in the C-terminal region of the protein . Association with inhibitory proteins of the IκB family retains NF-κB in the cytoplasm. Degradation of IB proteins exposes the nuclear localization sequence (NLS), leading to nuclear translocation and subsequent binding of NF-κB to DNA . p65 phosphorylation events occur in the cytoplasm or nucleus and are stimuli- and cell-type specific, on serines 276, 529, and 536 by various kinases: i.e. PKA, casein kinase II, IKK beta, and RSK1. Phosphorylation on these sites has been linked to the regulation of NF-κB activation.

• Выборка антител, приготовленных по технологии RMAb
• Полный перечень антител GeneTex

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